Lipid A and related compounds. XXX. Synthesis of biologically active N,N'-diacyl chitobiose derivatives structurally related to lipid A

Chem Pharm Bull (Tokyo). 1996 Oct;44(10):1958-61. doi: 10.1248/cpb.44.1958.

Abstract

Two new glycolipids, which mimic lipid A disaccharide, were synthesized from N,N'-diacylchitobiose via a key intermediate (2). They showed mitogenicity and nitric oxide (NO) productivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disaccharides*
  • Glucans / chemical synthesis
  • Glucans / chemistry*
  • Lipid A / chemistry*
  • Mitogens / chemical synthesis*
  • Nitric Oxide / metabolism

Substances

  • Disaccharides
  • Glucans
  • Lipid A
  • Mitogens
  • Nitric Oxide
  • chitobiose