Abstract
The paper presents experimental findings of the combined antiinfluenza drug (inactivated influenza vaccine + an interferon inducer - an immunogenetic anstimulator - polysaccharide 1,3beta-glucan). The oral immunization with the drug induces antibody accumulation in the secretions of the upper airway and blood sera in defense titers, interferon synthesis at days 1-3 postadministration, forms murine resistance to infection with homologous and heterologous viruses, enhances the functional activity of alveolar macrophages.
Publication types
-
Comparative Study
-
English Abstract
MeSH terms
-
Administration, Oral
-
Animals
-
Drug Combinations
-
Drug Evaluation, Preclinical
-
Glucans / administration & dosage
-
Glucans / immunology*
-
Immunity, Innate
-
Immunization / methods*
-
Influenza A virus / immunology*
-
Influenza Vaccines / administration & dosage
-
Influenza Vaccines / immunology*
-
Interferon Inducers / administration & dosage
-
Interferon Inducers / immunology*
-
Male
-
Mice
-
Orthomyxoviridae Infections / immunology
-
Orthomyxoviridae Infections / prevention & control*
-
Vaccines, Inactivated / administration & dosage
-
Vaccines, Inactivated / immunology
-
beta-Glucans*
Substances
-
Drug Combinations
-
Glucans
-
Influenza Vaccines
-
Interferon Inducers
-
Vaccines, Inactivated
-
beta-Glucans
-
beta-1,3-glucan