Abstract
Recent studies have revealed a correlation between amino acid sequences around glycosylation sites in proteoglycans and the ability of cells to initiate and process glycosaminoglycan chains. Initiation depends on Ser-Gly/Ala dipeptides that have one or more acidic amino acids in close proximity. The formation of heparan sulfate chains depends on a nearby cluster of acidic residues, hydrophobic amino acids, and the close spacing of glycosylation sites.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Glycosaminoglycans / chemistry*
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Humans
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Molecular Sequence Data
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Molecular Structure
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Sequence Analysis
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Viral Core Proteins / chemistry*
Substances
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Glycosaminoglycans
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Viral Core Proteins
Associated data
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GENBANK/A54949
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GENBANK/D50568
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GENBANK/L46768
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