Abstract
The density of protein gene product 9.5- and tyrosine hydroxylase-immunoreactive nerve fibers innervating circumvallate papillae of the tongue was substantially increased in transgenic mice that overexpressed nerve growth factor (NGF) when compared with age-matched controls. The fiber density was age-dependent. Only transgenic mice contained NGF-immunoreactive basal cells in the vicinity of taste buds, indicating that target-derived NGF induced novel hyperinnervation of the circumvallate papillae.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging / physiology*
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Animals
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Humans
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Immunohistochemistry
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Mice
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Mice, Transgenic
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Nerve Fibers / enzymology
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Nerve Fibers / physiology*
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Nerve Growth Factors / biosynthesis*
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Nerve Growth Factors / genetics
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Nerve Growth Factors / physiology
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Rats
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Taste Buds / physiology*
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Thiolester Hydrolases / biosynthesis
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Tyrosine 3-Monooxygenase / metabolism*
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Ubiquitin Thiolesterase
Substances
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Nerve Growth Factors
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Tyrosine 3-Monooxygenase
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Thiolester Hydrolases
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Ubiquitin Thiolesterase