Abstract
The circadian activity rhythm was assessed over a one-week period using a wrist-worn activity monitor in 59 patients with a history of recurrent suicide attempts. In 40 of these patients a second recording was made 6 months later. Platelet serotonin (5-HT) and monoamine oxidase-B activity (MAO) were measured. Suicidal ideation, borderline personality disorder and impulsiveness were associated with the absence of a clear 24-hour periodicity in motor activity. Depressive mood and hopelessness were associated with a less regular bed-in time and a lower daytime activity. Platelet 5-HT as well as MAO correlated negatively with the amplitude of the circadian activity rhythm. Our results support the suggested link between suicidality, altered circadian activity and serotonergic function.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Blood Platelets / enzymology*
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Borderline Personality Disorder / diagnosis
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Borderline Personality Disorder / physiopathology
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Borderline Personality Disorder / psychology
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Circadian Rhythm / physiology*
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Depressive Disorder / diagnosis
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Depressive Disorder / physiopathology
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Depressive Disorder / psychology
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Female
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Follow-Up Studies
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Humans
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Impulsive Behavior / diagnosis
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Impulsive Behavior / physiopathology
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Impulsive Behavior / psychology
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Male
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Monoamine Oxidase / blood*
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Motor Activity / physiology*
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Receptors, Serotonin / physiology
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Serotonin / blood*
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Suicide / psychology*
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Suicide Prevention
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Suicide, Attempted / prevention & control
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Suicide, Attempted / psychology*
Substances
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Receptors, Serotonin
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Serotonin
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Monoamine Oxidase