Molecular analysis of mixed infection with hepatitis C virus and human immunodeficiency virus in a patient infected simultaneously

J Med Virol. 1996 Nov;50(3):276-82. doi: 10.1002/(SICI)1096-9071(199611)50:3<276::AID-JMV11>3.0.CO;2-I.

Abstract

A case of simultaneous infection with HIV and HCV characterized by a rapidly progressive clinical course was studied retrospectively over 3.5 years. Molecular analysis indicated interference between HIV and HCV and between HCV subtypes 1a and 1b. An ineffective immune response was suggested by the persistence and sequence conservation of the HCV HVR1 variants isolated during the follow-up.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / virology*
  • Antiviral Agents / therapeutic use
  • Female
  • Follow-Up Studies
  • HIV Core Protein p24 / genetics
  • HIV-1 / isolation & purification*
  • Hepacivirus / classification*
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification
  • Hepatitis C / drug therapy
  • Hepatitis C / virology*
  • Humans
  • Interferon-alpha / therapeutic use
  • Longitudinal Studies
  • Middle Aged
  • Retrospective Studies
  • Viral Envelope Proteins / genetics
  • Zidovudine / therapeutic use

Substances

  • Antiviral Agents
  • E1 protein, Hepatitis C virus
  • HIV Core Protein p24
  • Interferon-alpha
  • Viral Envelope Proteins
  • Zidovudine