Video-assisted thoracoscopic surgical interruption (VTSI) of patent ductus arteriosus (PDA) is a relatively new technique when compared to surgical closure and transcatheter endovascular closure. Besides its minimally invasive nature, VTSI is the best option for neonates. Surgical approach may lead to late scoliosis in neonates and the vessels of neonates are too small for the transcatheter approach. VTSI potentially may prove to have lower morbidity and mortality than classic surgical closure of PDA. This article reviews the successful videothoracoscopic ligation of PDA in a 13-year-old girl.