Combination therapy with granulocyte colony-stimulating factor, all-trans retinoic acid, and low-dose cytotoxic drugs for acute myelogenous leukemia

Intern Med. 1995 Dec;34(12):1186-9. doi: 10.2169/internalmedicine.34.1186.

Abstract

A 67-year-old man presented with acute myelogenous leukemia (M2). Peripheral blood examination revealed a leukocyte count of 1,700/mu l with 1% myeloblasts, and bone marrow aspiration showed 42.6% myeloblasts with Auer bodies. Culture of his marrow cells at diagnosis showed that granulocyte colony-stimulating factor (G-CSF) promoted cell proliferation, while all-trans retinoic acid (ATRA) inhibited the proliferative effect of G-CSF and induced differentiation. Combination therapy with G-CSF, ATRA, and low-dose cytotoxic drugs achieved complete remission without severe marrow suppression.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Arabinonucleotides / therapeutic use*
  • Bone Marrow / drug effects
  • Cyclophosphamide / therapeutic use*
  • Cytidine Monophosphate / analogs & derivatives*
  • Cytidine Monophosphate / therapeutic use
  • Drug Therapy, Combination
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Tretinoin / therapeutic use*

Substances

  • Antineoplastic Agents
  • Arabinonucleotides
  • Immunosuppressive Agents
  • Granulocyte Colony-Stimulating Factor
  • 1-arabinofuranosylcytosine-5'-stearylphosphate
  • Tretinoin
  • Cyclophosphamide
  • Cytidine Monophosphate