Abstract
ZD1694 (Tomudex), a quinazoline folate analogue, is a potent and selective thymidylate synthase inhibitor. A phase II trial was undertaken to determine the efficacy and toxicity of ZD1694 in patients with advanced, measurable gastric adenocarcinoma. ZD1694, 3.0 mg/m2, was administered as a 15 min intravenous infusion every three weeks. Tumor measurements were obtained for response assessment every six weeks. Clinical examinations, adverse event assessments, and clinical laboratory tests were performed every three weeks. Thirty-three patients were enrolled. There were no objective responses to ZD1694. In general, treatment was well-tolerated. Grade 3 and 4 toxicities were infrequent, and included mucositis, nausea and vomiting, leukopenia, thrombocytopenia, and elevations of liver enzymes. Mild to moderate asthenia was common. Toxicities with ZD1694 were reversible and manageable. In conclusion, ZD1694 has an acceptable toxicity profile but shows no antitumor activity in patients with advanced gastric cancer.
Publication types
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Clinical Trial
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Clinical Trial, Phase II
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / pathology
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Adult
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Aged
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Alanine Transaminase / blood
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / adverse effects
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Antimetabolites, Antineoplastic / therapeutic use*
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Aspartate Aminotransferases / blood
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Asthenia / chemically induced
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Enzyme Inhibitors / administration & dosage
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Enzyme Inhibitors / adverse effects
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Enzyme Inhibitors / therapeutic use*
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Female
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Follow-Up Studies
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Humans
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Infusions, Intravenous
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Leukopenia / chemically induced
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Male
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Middle Aged
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Mucous Membrane / drug effects
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Nausea / chemically induced
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Neoplasm Staging
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Quinazolines / administration & dosage
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Quinazolines / adverse effects
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Quinazolines / therapeutic use*
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Remission Induction
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Thiophenes / administration & dosage
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Thiophenes / adverse effects
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Thiophenes / therapeutic use*
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Thrombocytopenia / chemically induced
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Thymidylate Synthase / antagonists & inhibitors*
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Vomiting / chemically induced
Substances
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Antimetabolites, Antineoplastic
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Enzyme Inhibitors
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Quinazolines
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Thiophenes
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Thymidylate Synthase
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Aspartate Aminotransferases
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Alanine Transaminase
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raltitrexed