20-Epi-vitamin D3 analogs. Potent modulators of proliferation and differentiation of breast cancer cell lines in vitro

E Elstner; D Heber; H P Koeffler

20-Epi-vitamin D3 analogs. Potent modulators of proliferation and differentiation of breast cancer cell lines in vitro

Adv Exp Med Biol. 1996:399:53-70.

Authors

E Elstner¹, D Heber, H P Koeffler

Affiliation

¹ Div. of Hematology-Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine 90048, USA.

PMID: 8937548

Abstract

Breast cancer is a devastating disease. New approach in therapy are needed. In this chapter, we describe our efforts to identify novel vitamin D3 analogs which may have a potent antiproliferative effect on breast cancer without causing hypercalcemia.

MeSH terms

Antineoplastic Agents / pharmacology*
Apoptosis
Breast Neoplasms / pathology*
Calcitriol / analogs & derivatives*
Calcitriol / pharmacology
Cell Differentiation / drug effects*
Cell Division / drug effects*
Cell Nucleus / metabolism
Humans
Immunohistochemistry
Proto-Oncogene Proteins c-bcl-2 / metabolism
Tumor Cells, Cultured
Tumor Suppressor Protein p53 / metabolism

Substances

Antineoplastic Agents
Proto-Oncogene Proteins c-bcl-2
Tumor Suppressor Protein p53
KH 1060
Calcitriol