Abstract
Sc1 and Sparc are two extracellular proteins sharing similarity in their carboxyl terminus, with 63% identity over a 232-amino-acid region. We have cloned and mapped the genomic locus of mouse Sc1. The mouse Sc1 gene contains 11 exons spanning approximately 35 kb of DNA. The genomic structure (exon/intron boundaries) of Sc1 exons 6 to exon 11 is identical to those of the similar portion of the Sparc gene. This suggests that Sc1 and Sparc originated from a common ancestral gene. Using fluorescence in situ hybridization analysis, Sc1 was localized to band 5E4 of mouse chromosome 5.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Activated-Leukocyte Cell Adhesion Molecule
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping
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Chromosomes
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Cloning, Molecular
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Evolution, Molecular
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Exons / genetics
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Extracellular Matrix Proteins / genetics*
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In Situ Hybridization, Fluorescence
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Mice
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Molecular Sequence Data
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Nerve Tissue Proteins / genetics*
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Osteonectin / genetics*
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Sequence Analysis
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Sequence Homology
Substances
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Activated-Leukocyte Cell Adhesion Molecule
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Extracellular Matrix Proteins
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Nerve Tissue Proteins
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Osteonectin
Associated data
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GENBANK/U64827
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GENBANK/U66157
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GENBANK/U66158
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GENBANK/U66159
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GENBANK/U66160
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GENBANK/U66161
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GENBANK/U66162
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GENBANK/U66163
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GENBANK/U66164
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GENBANK/U66165
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GENBANK/U66166