Abstract
A connective tissue disease resembling the human Ehlers-Danlos syndrome is reported in three Garafiano shepherd dogs from the same litter. The clinical signs included skin hyperextensibility and fragility, joint laxity, and ocular lesions. Microscopical studies showed abnormalities in the packing of collagen in fibrils and fibres in the skin. Systemic connective tissue defects were demonstrated in one necropsied puppy.
MeSH terms
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Animals
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Animals, Newborn / metabolism
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Animals, Newborn / physiology*
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Collagen / analysis
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Collagen / metabolism
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Collagen / ultrastructure
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Collagen Diseases / complications
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Collagen Diseases / diagnosis
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Collagen Diseases / veterinary*
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Connective Tissue Diseases / diagnosis
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Connective Tissue Diseases / physiopathology
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Connective Tissue Diseases / veterinary
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Dog Diseases / diagnosis*
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Dog Diseases / pathology
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Dog Diseases / physiopathology*
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Dogs
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Eye Diseases / etiology
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Eye Diseases / physiopathology
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Eye Diseases / veterinary
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Female
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Joint Instability / etiology
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Joint Instability / physiopathology
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Joint Instability / veterinary
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Lameness, Animal / etiology
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Lameness, Animal / physiopathology
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Male
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Microscopy, Electron / veterinary
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Skin / chemistry
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Skin / metabolism
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Skin / pathology