Abstract
Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.
Publication types
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Clinical Trial
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Clinical Trial, Phase II
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Antidotes / therapeutic use*
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Antidotes / toxicity
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Antimetabolites, Antineoplastic / therapeutic use*
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Antimetabolites, Antineoplastic / toxicity
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Astrocytoma / drug therapy*
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Brain Neoplasms / drug therapy*
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Female
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Fluorouracil / therapeutic use*
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Fluorouracil / toxicity
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Humans
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Leucovorin / therapeutic use*
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Leucovorin / toxicity
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Leukopenia / chemically induced
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Male
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Middle Aged
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Oligodendroglioma / drug therapy*
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Recurrence
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Stomatitis / chemically induced
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Thrombocytopenia / chemically induced
Substances
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Antidotes
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Antimetabolites, Antineoplastic
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Leucovorin
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Fluorouracil