Abstract
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphate / metabolism
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Biological Transport, Active
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Cell Line
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Cysteine Endopeptidases / metabolism*
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Cytomegalovirus / immunology
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Cytosol / metabolism
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Endoplasmic Reticulum / metabolism*
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Glycosylation
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Histocompatibility Antigens Class I / metabolism
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Humans
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Membrane Proteins / metabolism*
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Multienzyme Complexes / metabolism*
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Proteasome Endopeptidase Complex
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Protein Folding
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SEC Translocation Channels
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Viral Proteins / immunology
Substances
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Histocompatibility Antigens Class I
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Membrane Proteins
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Multienzyme Complexes
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SEC Translocation Channels
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Viral Proteins
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Adenosine Triphosphate
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Cysteine Endopeptidases
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Proteasome Endopeptidase Complex