Influence of cloned tRNA genes from a uropathogenic Escherichia coli strain on adherence to primary human renal tubular epithelial cells and nephropathogenicity in rats

M Susa; B Kreft; G Wasenauer; A Ritter; J Hacker; R Marre

doi:10.1128/iai.64.12.5390-5394.1996

Influence of cloned tRNA genes from a uropathogenic Escherichia coli strain on adherence to primary human renal tubular epithelial cells and nephropathogenicity in rats

Infect Immun. 1996 Dec;64(12):5390-4. doi: 10.1128/iai.64.12.5390-5394.1996.

Authors

M Susa¹, B Kreft, G Wasenauer, A Ritter, J Hacker, R Marre

Affiliation

¹ Klinikum, Abteilung für Medizinische Mikrobiologie und Hygiene der Universität Ulm, Germany.

Abstract

The uropathogenic Escherichia coli strain 536 (O6:K15:H31) possesses pathogenicity islands which are incorporated into two tRNA genes, the selC and the leuX gene. The leuX gene influences the expression of different putative virulence factors. We demonstrate an effect of the leuX-specific tRNA on adherence and uropathogenicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacterial Adhesion / genetics*
Cells, Cultured
Escherichia coli / genetics*
Escherichia coli / pathogenicity
Gene Expression Regulation, Bacterial
Humans
Kidney Tubules / microbiology*
Kidney Tubules / pathology
RNA, Bacterial / genetics*
RNA, Transfer / genetics*
Rats

Substances

RNA, Bacterial
RNA, Transfer