Abstract
Effects of ulinastatin (a Kunitz-type proteinase inhibitor) administration was examined in a model of acute ischemic renal injury induced by bilateral renal artery occlusion in rats. Compared with rats administered vehicle, rats administered ulinastatin (150,000 U/kg body weight) intravenously 30 min preischemia had significantly lower serum creatinine and blood urea nitrogen, and much less injury evident by examination of kidney histologies over the course of 48 h postreperfusion. We conclude that ulinastatin exerts a protective effect against ischemic renal injury.
MeSH terms
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Animals
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Blood Urea Nitrogen
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Creatinine / blood
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Creatinine / metabolism*
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Disease Models, Animal
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Endopeptidases / drug effects
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Endopeptidases / metabolism
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Glycoproteins / administration & dosage
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Glycoproteins / therapeutic use*
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Injections, Intravenous
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Ischemia / drug therapy*
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Kidney / blood supply*
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Kidney / injuries
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Kidney Function Tests
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Kidney Tubular Necrosis, Acute / drug therapy*
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Kidney Tubular Necrosis, Acute / pathology
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Male
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Rats
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Rats, Sprague-Dawley
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Reference Values
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Trypsin Inhibitors / administration & dosage
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Trypsin Inhibitors / therapeutic use*
Substances
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Glycoproteins
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Trypsin Inhibitors
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Creatinine
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Endopeptidases
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urinastatin