Abstract
Purpose:
To describe a case of acute retinal necrosis with concurrent encephalitis and determine the causative virus. The patient had a history of presumed acute retinal necrosis in the left eye at the age of 8 years and recurrent genital herpes.
Methods:
Diagnostic anterior chamber puncture of the eye and lumbar puncture for laboratory analysis.
Results:
Polymerase chain reaction identified herpes simplex virus type 2 in the eye, and local antibody production to herpes simplex virus was demonstrated in the aqueous of this eye and in the cerebrospinal fluid.
Conclusion:
Herpes simplex virus type 2 may cause bilateral acute retinal necrosis with long delay of fellow eye involvement and concurrent encephalitis.
MeSH terms
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Acyclovir / therapeutic use
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Adult
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Antibodies, Viral / analysis
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Antiviral Agents / therapeutic use
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Aqueous Humor / virology
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Cerebrospinal Fluid / virology
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Combined Modality Therapy
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DNA, Viral / analysis
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Encephalitis, Viral / diagnosis
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Encephalitis, Viral / etiology
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Encephalitis, Viral / therapy
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Eye Infections, Viral / diagnosis
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Eye Infections, Viral / etiology*
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Eye Infections, Viral / therapy
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Female
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Fluorescein Angiography
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Fundus Oculi
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Herpes Genitalis / etiology
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Herpes Simplex / diagnosis
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Herpes Simplex / etiology*
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Herpes Simplex / therapy
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Herpesvirus 2, Human* / genetics
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Herpesvirus 2, Human* / immunology
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Herpesvirus 2, Human* / isolation & purification
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Humans
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Laser Therapy
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Polymerase Chain Reaction
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Recurrence
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Retinal Necrosis Syndrome, Acute / diagnosis
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Retinal Necrosis Syndrome, Acute / therapy
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Retinal Necrosis Syndrome, Acute / virology*
Substances
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Antibodies, Viral
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Antiviral Agents
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DNA, Viral
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Acyclovir