Abstract
New aminothienopyrimidines and derivatives of the new thienotriazolopyrimidine ring system were synthesized to investigate their anticonvulsant activity. The tricyclic compounds 6a, c, e, f, m, o and p and two bicyclic derivatives 4f and 4o were tested. The pharmacological screening results are reported and discussed.
MeSH terms
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Male
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Mice
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Motor Activity / drug effects
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Rats
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Seizures / prevention & control
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / pharmacology
Substances
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Anticonvulsants
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Pyrimidines
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Thiophenes
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Triazoles