People infected with HIV have a greater risk of developing malignancies. The most frequent one is the Kaposi's sarcoma (KS). The second is the Non-Hodgkin's lymphoma (NHL). We report six cases of NHL in association with HIV infection (NHL-HIV) of the head and neck. Three of them had extranodal location (2 oral lymphomas and one case affecting the maxillary sinus). The other 3 cases were located in the cervical nodes. The oral malignancies were treated with radiotherapy (RT). Chemotherapy was applied to the other 4. Only one of our patients has survived more than two years. In one case the NHL was the first manifestation of the infection with HIV. Diagnosis of extranodal NHL requires search for AIDS.