Abstract
We have identified a highly informative dinucleotide repeat in the 5'-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18-37 copies of a (CT) repeat with an observed heterozygosity of 82-83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13-15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Black People / genetics
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Black or African American
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Chromosome Mapping
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Chromosomes, Human, Pair 12*
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DNA Primers
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Gene Frequency
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Genetic Linkage
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Genetic Markers
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HMGA2 Protein
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High Mobility Group Proteins / biosynthesis
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High Mobility Group Proteins / genetics*
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Humans
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Microsatellite Repeats
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Nuclear Proteins / genetics
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Pedigree
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Pennsylvania
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Recombination, Genetic
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White People / genetics
Substances
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DNA Primers
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Genetic Markers
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HMGA2 Protein
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High Mobility Group Proteins
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Nuclear Proteins