Meningeal involvement in Wegener's granulomatosis confirmed and monitored by positive circulating antineutrophil cytoplasm in cerebrospinal fluid

M Spranger; S Schwab; H M Meinck; M Tischendorf; J Sis; A Breitbart; K Andrassy

doi:10.1212/wnl.48.1.263

Meningeal involvement in Wegener's granulomatosis confirmed and monitored by positive circulating antineutrophil cytoplasm in cerebrospinal fluid

Neurology. 1997 Jan;48(1):263-5. doi: 10.1212/wnl.48.1.263.

Authors

M Spranger¹, S Schwab, H M Meinck, M Tischendorf, J Sis, A Breitbart, K Andrassy

Affiliation

¹ Department of Neurology, University of Heidelberg, Germany.

PMID: 9008530
DOI: 10.1212/wnl.48.1.263

Abstract

MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activity by c-ANCA measurement in the CSF. After repeated cycles of intrathecal administration of methotrexate and corticoids, progression of meningeal infiltration stopped, and CSF c-ANCA titers became negative.

Publication types

Case Reports

MeSH terms

Adult
Antibodies / analysis
Antibodies, Antineutrophil Cytoplasmic / cerebrospinal fluid*
Dexamethasone / therapeutic use
Drug Therapy, Combination
Granulomatosis with Polyangiitis / cerebrospinal fluid*
Granulomatosis with Polyangiitis / immunology
Granulomatosis with Polyangiitis / pathology*
Humans
Magnetic Resonance Imaging
Male
Meninges / pathology*
Methotrexate / therapeutic use
Methylprednisolone / therapeutic use
Myeloblastin
Serine Endopeptidases / immunology

Substances

Antibodies
Antibodies, Antineutrophil Cytoplasmic
Dexamethasone
Serine Endopeptidases
Myeloblastin
Methylprednisolone
Methotrexate