Simultaneous formation of peptides and nucleotides from N-phosphothreonine

Orig Life Evol Biosph. 1996 Dec;26(6):547-60. doi: 10.1007/BF01808220.

Abstract

An intramolecular mutual activation between a phosphoryl group and carboxyl group results in the simultaneous formation of nucleotides and peptides by the reaction of nucleosides with N-(O,O-diisopropyl)phosphothreonine in anhydrous pyridine. These results suggest pathways for the simultaneous prebiotic synthesis of peptides and oligonucleotides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Electrophoresis, Capillary
  • Nucleosides / chemistry
  • Nucleotides / chemistry*
  • Peptides / chemistry*
  • Phosphothreonine / chemistry*
  • Spectrophotometry, Ultraviolet

Substances

  • Nucleosides
  • Nucleotides
  • Peptides
  • Phosphothreonine