The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck

Res Virol. 1997 Jan-Feb;148(1):52-8. doi: 10.1016/s0923-2516(97)81914-0.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis*
  • Gene Products, nef / physiology*
  • HIV-1 / physiology*
  • Humans
  • Interleukin-2 / biosynthesis
  • Lymphocyte Activation
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • Receptors, Antigen, T-Cell / immunology
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / virology
  • Th1 Cells / immunology*
  • Th2 Cells / immunology
  • Transcription Factor AP-1 / metabolism
  • nef Gene Products, Human Immunodeficiency Virus
  • src-Family Kinases / metabolism*

Substances

  • Cytokines
  • Gene Products, nef
  • Interleukin-2
  • Receptors, Antigen, T-Cell
  • Transcription Factor AP-1
  • nef Gene Products, Human Immunodeficiency Virus
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • src-Family Kinases