A 50-year-old man with gallbladder cancer was treated by extended cholecystectomy and regional lymph node dissection. At 13 months after surgery, CEA showed high serum levels, and an enlarged liver tumor due to recurrence was demonstrated by computed tomography. After arterial infusion chemotherapy consisting of CDDP, epirubicin and 5-FU, the tumor size and serum level of CEA were significantly decreased. After this therapy and transcatheter arterial embolization, the liver tumor markedly responded and became undetectable. It was suggested that this therapy was effective for gallbladder cancer.