Abstract
Uracil derivatives bearing substituted or unsubstituted vinyl groups at position C6 and alkyl- or arylthio groups at position C5 were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds were active against HIV-1. However, some of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations. The maximum potency of antiproliferative activity correlates with the presence of unsubstituted vinyl groups and alkyl- or arylthio substituents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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HIV-1 / drug effects
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Humans
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Thionucleotides / chemical synthesis*
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Thionucleotides / pharmacology
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Tumor Cells, Cultured
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Uracil / analogs & derivatives*
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Uracil / chemical synthesis
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Uracil / pharmacology
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Vinyl Compounds / chemical synthesis*
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Vinyl Compounds / pharmacology
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Thionucleotides
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Vinyl Compounds
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Uracil