Abstract
We examined chemokine receptors for the ability to facilitate the infection of CD4-expressing cells by viruses containing the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion. Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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CD4-Positive T-Lymphocytes / immunology*
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DNA, Viral
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Gene Products, env / genetics
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Gene Products, env / immunology*
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HeLa Cells
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Humans
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Molecular Sequence Data
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Receptors, CCR5
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Receptors, Cytokine / immunology*
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Receptors, HIV / immunology*
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / isolation & purification
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Simian Immunodeficiency Virus / physiology*
Substances
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DNA, Viral
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Gene Products, env
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Receptors, CCR5
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Receptors, Cytokine
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Receptors, HIV