Abstract
We describe 3 Japanese patients having both serum anti-DNA topoisomerase I and anti-Sm antibodies. All 3 patients had typical features of systemic lupus erythematosus, such as glomerulonephritis, in addition to skin thickening and systemic sclerosis related organ involvement, including pulmonary interstitial fibrosis and renal crisis. This is the first report of the coexistence of these 2 disease specific autoantibodies.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antibodies, Antinuclear / analysis*
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Autoantigens / immunology*
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DNA Topoisomerases, Type I / immunology*
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Electrophoresis
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Female
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Humans
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Kidney Glomerulus / pathology
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Lupus Erythematosus, Systemic / complications*
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Lupus Erythematosus, Systemic / immunology
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Ribonucleoproteins, Small Nuclear / immunology*
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Scleroderma, Systemic / complications*
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Scleroderma, Systemic / immunology
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snRNP Core Proteins
Substances
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Antibodies, Antinuclear
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Autoantigens
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Ribonucleoproteins, Small Nuclear
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snRNP Core Proteins
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DNA Topoisomerases, Type I