Abstract
The mechanisms involved in the maintenance of staphylococcal enterotoxin B (SEB)-induced T cell anergy are poorly understood. Here, we demonstrate that CD4+ T cell anergy induced by SEB treatment is under partial B cell control. This effect is not mediated by anti-SEB antibodies or any in vitro B cell-produced suppresser factor. At day 13 after SEB immunization, T cells from B cell-deficient mice proliferate upon in vitro stimulation with SEB. These results suggest that SEB-induced T cell anergy is reversible and that B cells have an important function in anergy maintenance in CD4+ T cells, both in vivo and in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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CD4-Positive T-Lymphocytes / immunology*
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Cells, Cultured
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Clonal Anergy / drug effects*
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Enterotoxins / pharmacology*
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Female
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Interleukin-2 / biosynthesis
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Lymphocyte Activation
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Lymphopenia / genetics
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Macrophages / immunology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Mutant Strains
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-fyn
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Staphylococcus aureus / immunology*
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src-Family Kinases / metabolism
Substances
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Enterotoxins
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Interleukin-2
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Proto-Oncogene Proteins
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enterotoxin B, staphylococcal
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Fyn protein, mouse
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Proto-Oncogene Proteins c-fyn
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src-Family Kinases