Abstract
Imipramine-N-oxide, quinupramine, clomipramine, doxepin, maprotiline, amineptine, amoxapine, mianserin, minaprine, nomifensine, viloxacine, trazodone and lofepramine effects were studied on rat vas deferens responses to noradrenaline. Tissues were prepared in Krebs-Henseleit solution with and without adding cocaine. 17 beta-estradiol and propranolol for blocking neuronal and extraneuronal noradrenaline reuptake. In normal Krebs-Henseleit solution imipramine-N-oxide, nomifensine, viloxacine and lofepramine increased noradrenaline responses, while clomipramine, trazodone and doxepin behaved as competitive antagonists. When adding cocaine, 17 beta-estradiol and propranolol to the solution there was antagonism but no increase in responses.
MeSH terms
-
Adrenergic alpha-Agonists / pharmacology
-
Adrenergic beta-Antagonists / pharmacology
-
Animals
-
Antidepressive Agents / pharmacology*
-
Antidepressive Agents, Tricyclic / pharmacology
-
Binding, Competitive
-
Cocaine / pharmacology
-
Dopamine Uptake Inhibitors / pharmacology
-
Dose-Response Relationship, Drug
-
Estradiol / pharmacology
-
Male
-
Norepinephrine / antagonists & inhibitors*
-
Norepinephrine / pharmacology
-
Propranolol / pharmacology
-
Rats
-
Rats, Wistar
-
Receptors, Adrenergic, alpha-1 / drug effects*
-
Receptors, Adrenergic, alpha-1 / physiology
-
Vas Deferens / drug effects*
Substances
-
Adrenergic alpha-Agonists
-
Adrenergic beta-Antagonists
-
Antidepressive Agents
-
Antidepressive Agents, Tricyclic
-
Dopamine Uptake Inhibitors
-
Receptors, Adrenergic, alpha-1
-
Estradiol
-
Propranolol
-
Cocaine
-
Norepinephrine