31P NMR spectroscopy in oligonucleotide research and development

B L Hirschbein; K L Fearon

doi:10.1089/oli.1.1997.7.55

31P NMR spectroscopy in oligonucleotide research and development

Antisense Nucleic Acid Drug Dev. 1997 Feb;7(1):55-61. doi: 10.1089/oli.1.1997.7.55.

Authors

B L Hirschbein¹, K L Fearon

Affiliation

¹ Lynx Therapeutics, Hayward, California 94545, USA.

PMID: 9055040
DOI: 10.1089/oli.1.1997.7.55

Abstract

31P NMR is an extremely valuable tool for oligonucleotide research and development. This brief commentary, which is directed to scientists who do not regularly use 31P NMR in their work, attempts to outline some of the principles, considerations, and representative applications of 31P NMR spectroscopy in oligonucleotide research and development.

Publication types

Review

MeSH terms

Drug Stability
Isotope Labeling
Magnetic Resonance Spectroscopy / methods*
Oligonucleotides / analysis
Oligonucleotides / chemical synthesis
Oligonucleotides / chemistry*
Phosphorus Isotopes
Quality Control

Substances

Oligonucleotides
Phosphorus Isotopes