The effects of a 4.7 tesla static magnetic field on the frequency of micronucleated cells induced by mitomycin C

Tohoku J Exp Med. 1996 Nov;180(3):209-15. doi: 10.1620/tjem.180.209.

Abstract

The effects of a 4.7 tesla (T) static magnetic field (SMF) on the frequency of micronucleated cells (MN-cells) in CHL/IU cells induced by mitomycin C (MMC) were studied in vitro. Exposure to a 4.7 T SMF for 6 hr significantly decreased the frequency of MMC-induced MN-cells for expression culture periods of 18, 42, 54 and 66 hr. The highest frequency of MMC-induced MN-cells was observed at the expression culture period of 42 hr and decreased gradually in the same manner in both exposed and control groups. These results suggest that a 4.7 T SMF may exert on influence during the DNA damage stage produced by MMC rather than on the formation of micronuclei during the stage following MMC-induced DNA damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Nucleus / drug effects*
  • Cell Nucleus / ultrastructure*
  • Cricetinae
  • Cricetulus
  • Dose-Response Relationship, Drug
  • Electromagnetic Fields*
  • Mitomycin / pharmacology*
  • Time Factors

Substances

  • Mitomycin