Abstract
A number of quinazoline derivatives containing basic amine substituents at position 4, as well as new derivatives of triazolo[4,3-alpha]quinoxalines carrying basic amine or carboxylic acid moieties have been synthesized. A tetracyclic imidazotriazoloquinoxaline compound is also reported. Two of the new products (2b and 7b) exhibited good antiinflammatory activity in rats, although inferior to that of indomethacin.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control
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Quinazolines / chemical synthesis*
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Quinazolines / pharmacology
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Quinoxalines / chemical synthesis*
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Quinoxalines / pharmacology
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Rats
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Quinazolines
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Quinoxalines
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Carrageenan