The physical and genetic map surrounding the Lyst gene on mouse chromosome 13

D J Misumi; D L Nagle; S H McGrail; B J Dussault Jr; J S Smutko; H Chen; O Charlat; G M Duyk; C Ebeling; L Baldini; G A Carlson; K J Moore

doi:10.1006/geno.1996.4549

The physical and genetic map surrounding the Lyst gene on mouse chromosome 13

Genomics. 1997 Feb 15;40(1):147-50. doi: 10.1006/geno.1996.4549.

Authors

D J Misumi¹, D L Nagle, S H McGrail, B J Dussault Jr, J S Smutko, H Chen, O Charlat, G M Duyk, C Ebeling, L Baldini, G A Carlson, K J Moore

Affiliation

¹ Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.

PMID: 9070932
DOI: 10.1006/geno.1996.4549

Abstract

During the recent cloning of the mouse Lyst gene we developed both a high-resolution genetic map and a complete YAC and BAC contig of the Lyst critical region on mouse Chromosome 13. We also report the mapping of the human homologue of the mouse Lyst gene (LYST) to 1q43. These data are consistent with LYST being the gene for the human Chediak-Higashi Syndrome and strengthen the synteny relationship between MMU13 and human 1q43.

MeSH terms

Animals
Base Sequence
Chromosome Mapping*
Chromosomes, Human, Pair 1
DNA, Complementary
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Molecular Sequence Data
Proteins / genetics*
Vesicular Transport Proteins

Substances

DNA, Complementary
Intracellular Signaling Peptides and Proteins
LYST protein, human
Lyst protein, mouse
Proteins
Vesicular Transport Proteins

Associated data

GENBANK/L19698
GENBANK/R24078
GENBANK/U00776
GENBANK/U52461
GENBANK/U67615