Immunology: what is the proximal cause of inflammation?

Curr Biol. 1997 Jan 1;7(1):R41-3. doi: 10.1016/s0960-9822(06)00017-0.

Abstract

Knockout mice lacking either the antibody constant region (Fc) receptor or the substance P receptor fail to produce a model inflammatory response, implicating these two receptors in early events of inflammation.

MeSH terms

  • Animals
  • Arthus Reaction / physiopathology
  • Humans
  • Inflammation / physiopathology*
  • Mice
  • Mice, Knockout
  • Receptors, Fc / genetics
  • Receptors, Fc / physiology
  • Receptors, Neurokinin-1 / genetics
  • Receptors, Neurokinin-1 / physiology

Substances

  • Receptors, Fc
  • Receptors, Neurokinin-1