Abstract
Clozapine often causes low-grade fever and less frequently spiking fever. We describe three cases of spiking fever that occurred in the first 3 weeks of clozapine therapy. A new set of side effects of clozapine is identified, which includes spiking fever, respiratory and gastrointestinal symptoms, and neutrophilia. Possible mechanisms are discussed.
MeSH terms
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Adult
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Antipsychotic Agents / adverse effects*
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Clozapine / adverse effects*
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Female
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Fever / chemically induced*
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Gastrointestinal Diseases / chemically induced
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Humans
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Leukocyte Count
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Lung Diseases / chemically induced
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Male
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Neutrophils
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Psychotic Disorders / drug therapy
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Schizophrenia, Paranoid / drug therapy
Substances
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Antipsychotic Agents
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Clozapine