[Isolated hyperthermic perfusion of extremities in malignant melanoma with melphalan and tumor necrosis factor]

C Kettelhack; P Hohenberger; P M Schlag

[Isolated hyperthermic perfusion of extremities in malignant melanoma with melphalan and tumor necrosis factor]

Langenbecks Arch Chir Suppl Kongressbd. 1996:113:127-9.

[Article in German]

Authors

C Kettelhack¹, P Hohenberger, P M Schlag

Affiliation

¹ Humboldt-Universität, Virchow-Klinikum, Robert-Rössle-Klinik, Berlin.

PMID: 9101810

Abstract

Isolated limb perfusion (ILP) with tumor necrosis factor (TNF) and melphalan was carried out in 21 patients with regionally metastatic malignant melanoma of the limbs. The observed response rate was 65% complete and 15% partial remission. These results warrant further investigation of ILP with TNF and melphalan vs ILP with melphalan alone in a prospective randomised multicenter trial.

Publication types

English Abstract

MeSH terms

Antineoplastic Agents, Alkylating / administration & dosage*
Chemotherapy, Cancer, Regional Perfusion / methods*
Combined Modality Therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Extremities*
Female
Humans
Male
Melanoma / pathology
Melanoma / therapy*
Melphalan / administration & dosage*
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / therapy
Neoplasm Staging
Skin Neoplasms / pathology
Skin Neoplasms / therapy*
Treatment Outcome
Tumor Necrosis Factor-alpha / administration & dosage*

Substances

Antineoplastic Agents, Alkylating
Tumor Necrosis Factor-alpha
Melphalan