Attempts to use liposomes and RBC ghosts as vectors in drug and antisense therapy of virus infection

S Grimaldi; A Lisi; D Pozzi; N Santoro

doi:10.1016/s0923-2516(97)89906-2

Attempts to use liposomes and RBC ghosts as vectors in drug and antisense therapy of virus infection

Res Virol. 1997 Mar-Apr;148(2):177-80. doi: 10.1016/s0923-2516(97)89906-2.

Authors

S Grimaldi¹, A Lisi, D Pozzi, N Santoro

Affiliation

¹ Istituto di Medicina Sperimentale C.N.R., Roma, Italy.

PMID: 9108622
DOI: 10.1016/s0923-2516(97)89906-2

Abstract

Selective targeting of drugs or oligonucleotide for the treatment of viral diseases or cancer is the objective of new strategies that pursue therapy optimization and reduction of toxicity. In this work we report two protocols based on encapsulation of anti-human immunodeficiency virus drugs within targeted liposomes or erythrocytes. Both have been shown to be effective for the specific delivery of drugs or oligonucleotide in the treatment of viral infection.

MeSH terms

Adenine / administration & dosage
Adenine / analogs & derivatives*
Adenine / pharmacology
Antiviral Agents / administration & dosage*
Antiviral Agents / pharmacology
Cells, Cultured
Drug Carriers
Erythrocyte Membrane*
HIV-1 / drug effects
Humans
Liposomes
Oligonucleotides, Antisense / administration & dosage*
Oligonucleotides, Antisense / pharmacology
Organophosphonates*
Virus Diseases / drug therapy*

Substances

Antiviral Agents
Drug Carriers
Liposomes
Oligonucleotides, Antisense
Organophosphonates
adefovir
Adenine