Abstract
Acute and chronic stimulation of GH secretion occurred after administration of MK-677 in normal elderly subjects and IGF-I was increased during four weeks of treatment. The activation of the GH/ IGF-I axis was achieved without adversely affecting ACTH, cortisol or prolactin secretion.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adipose Tissue / anatomy & histology
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Adipose Tissue / drug effects
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Adolescent
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Adult
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Aged
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Aging / blood
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Aging / pathology
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Aging / physiology*
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Awards and Prizes
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Child
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Clinical Medicine
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Female
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Human Growth Hormone / deficiency
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Human Growth Hormone / metabolism*
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Humans
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Hydrocortisone / blood
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Indoles / pharmacology
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Insulin-Like Growth Factor I / metabolism
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Male
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Middle Aged
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Oligopeptides / pharmacology
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Prolactin / blood
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Societies, Medical
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Spiro Compounds / pharmacology
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United States
Substances
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Indoles
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Oligopeptides
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Spiro Compounds
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Human Growth Hormone
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growth hormone releasing hexapeptide
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Insulin-Like Growth Factor I
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Prolactin
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ibutamoren mesylate
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Hydrocortisone