Coexistence of tetrasomy 8 and trisomy 8 in a case with myeloid metaplasia with myelofibrosis

F Solé; J M de Pablos; S Woessner; M M Pérez; M Jurado; B Espinet; P Grao; A Moratalla; J Esquivias

doi:10.1016/s0165-4608(96)00206-3

Coexistence of tetrasomy 8 and trisomy 8 in a case with myeloid metaplasia with myelofibrosis

Cancer Genet Cytogenet. 1997 Apr;94(2):147-50. doi: 10.1016/s0165-4608(96)00206-3.

Authors

F Solé¹, J M de Pablos, S Woessner, M M Pérez, M Jurado, B Espinet, P Grao, A Moratalla, J Esquivias

Affiliation

¹ Laboratori de Citologia Hematologica, Hospital Central l'Aliança, Barcelona, Spain.

PMID: 9109946
DOI: 10.1016/s0165-4608(96)00206-3

Abstract

We present a case of myeloid metaplasia with myelofibrosis (MM/MF), with tetrasomy 8 as the sole cytogenetic abnormality detected by conventional cytogenetic studies. Tetrasomy 8 was also detected by in situ interphase studies and confirmed by chromosome painting in metaphase. To our knowledge, this is the first case of MM/MF with tetrasomy 8. Noteworthy is the association with neurofibromatosis.

Publication types

Case Reports

MeSH terms

Adult
Chromosomes, Human, Pair 8*
Female
Humans
In Situ Hybridization, Fluorescence
Neurofibromatoses / complications
Polyploidy
Primary Myelofibrosis / complications*
Primary Myelofibrosis / genetics*
Primary Myelofibrosis / pathology
Trisomy