Abstract
The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb. Its formation is directed by the boundary between cells that do and cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Avian Proteins
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Biological Evolution
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Body Patterning / genetics
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Body Patterning / physiology
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Chick Embryo
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Cloning, Molecular
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Drosophila / embryology
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Drosophila Proteins
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Ectoderm / physiology
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Embryonic Induction / physiology
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Gene Expression
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Genetic Vectors
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Glycosyltransferases*
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Homeodomain Proteins / physiology
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In Situ Hybridization
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Limb Buds / embryology*
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Limb Buds / physiology
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Membrane Proteins / metabolism
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Mutation
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Protein Biosynthesis
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Proteins / genetics
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Proteins / physiology*
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Receptors, Notch
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Retroviridae / genetics
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Signal Transduction
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Wings, Animal / embryology
Substances
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Avian Proteins
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Drosophila Proteins
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Homeodomain Proteins
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Membrane Proteins
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N protein, Drosophila
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Proteins
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Receptors, Notch
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Glycosyltransferases
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LFNG protein, Gallus gallus
Associated data
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GENBANK/U91849
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GENBANK/U91850
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GENBANK/U91851