C-peptide does not alter carbohydrate metabolism in isolated mouse muscle

P N Shashkin; Y Jiao; H Westerblad; A Katz

doi:10.1152/ajpendo.1997.272.2.E245

C-peptide does not alter carbohydrate metabolism in isolated mouse muscle

Am J Physiol. 1997 Feb;272(2 Pt 1):E245-7. doi: 10.1152/ajpendo.1997.272.2.E245.

Authors

P N Shashkin¹, Y Jiao, H Westerblad, A Katz

Affiliation

¹ Division of Clinical Physiology, Department of Surgical Sciences, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.

PMID: 9124330
DOI: 10.1152/ajpendo.1997.272.2.E245

Abstract

The effects of C-peptide on carbohydrate metabolism in isolated mouse soleus muscle were studied. C-peptide, at concentrations up to 1,000 nM, had no effect on [14C]glucose incorporation into glycogen, glycogen synthase activity, or 2-deoxyglucose uptake. These data demonstrate that C-peptide has no direct effect on the measured parameters of carbohydrate metabolism in isolated mouse muscle.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
C-Peptide / pharmacology*
Carbohydrate Metabolism*
Deoxyglucose / pharmacokinetics
Glycogen / biosynthesis
Glycogen Synthase / metabolism
In Vitro Techniques
Insulin / pharmacology
Male
Mice
Muscle, Skeletal / drug effects*
Muscle, Skeletal / metabolism*
Osmolar Concentration
Rats

Substances

C-Peptide
Insulin
Glycogen
Deoxyglucose
Glycogen Synthase