Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

R M Duberley; I P Johnson; P Anand; P N Leigh; N J Cairns

doi:10.1016/s0022-510x(96)00312-7

Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

J Neurol Sci. 1997 May 1;148(1):33-40. doi: 10.1016/s0022-510x(96)00312-7.

Authors

R M Duberley¹, I P Johnson, P Anand, P N Leigh, N J Cairns

Affiliation

¹ Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.

PMID: 9125388
DOI: 10.1016/s0022-510x(96)00312-7

Abstract

We have demonstrated neurotrophin-3 (NT-3)-like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Amyotrophic Lateral Sclerosis / metabolism*
Female
Gene Expression / physiology
Humans
Immunohistochemistry
In Situ Hybridization
Male
Middle Aged
Motor Neurons / chemistry*
Motor Neurons / physiology
Nerve Growth Factors / analysis
Nerve Growth Factors / immunology*
Neurotrophin 3
RNA, Messenger / analysis
Receptor Protein-Tyrosine Kinases / genetics*
Receptor, trkC
Receptors, Nerve Growth Factor / genetics*
Spinal Cord / cytology*

Substances

Nerve Growth Factors
Neurotrophin 3
RNA, Messenger
Receptors, Nerve Growth Factor
Receptor Protein-Tyrosine Kinases
Receptor, trkC