Abstract
Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at approximately 25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging
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Animals
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B-Lymphocytes / pathology
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Borrelia / classification*
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Borrelia / isolation & purification
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Borrelia Infections / pathology
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Borrelia Infections / physiopathology*
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Brain / pathology*
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Humans
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Meningitis, Bacterial / pathology
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Meningitis, Bacterial / physiopathology*
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Meningoencephalitis / pathology
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Meningoencephalitis / physiopathology*
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Mice
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Mice, Inbred C3H
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Monocytes / pathology
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Plasma Cells / pathology
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Relapsing Fever / microbiology
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Time Factors