Abstract
Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins / physiology
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Fungal Proteins / physiology
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Gene Expression Regulation*
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Genes, myc
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Histone Deacetylases / physiology*
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Humans
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Mice
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Nuclear Proteins / physiology*
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Nuclear Receptor Co-Repressor 1
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Repressor Proteins / physiology*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins*
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Transcription Factors / physiology*
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Transcription, Genetic
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Tumor Suppressor Proteins
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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Fungal Proteins
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MXI1 protein, human
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Mxi1 protein, mouse
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NCOR1 protein, human
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Ncor1 protein, mouse
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Nuclear Proteins
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Nuclear Receptor Co-Repressor 1
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PAH2 protein, Pichia angusta
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Recombinant Fusion Proteins
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Repressor Proteins
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SIN3 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Tumor Suppressor Proteins
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Histone Deacetylases