Abstract
In the past year we have gained significant insights into the molecular and genetic mechanisms underlying generalized absence seizures, primarily through the study of animal models. Also a new understanding has emerged about the genetic bases of certain syndromes in which generalized myoclonic and tonic-clonic seizures are expressed. New insights into these different types of generalized seizures may lead eventually to new therapies.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Brain / abnormalities
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Brain / physiopathology
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Epilepsies, Myoclonic / genetics
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Epilepsies, Myoclonic / physiopathology
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Epilepsy, Absence / genetics
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Epilepsy, Absence / physiopathology
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Epilepsy, Generalized / genetics*
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Epilepsy, Generalized / physiopathology
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Epilepsy, Tonic-Clonic / genetics
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Epilepsy, Tonic-Clonic / physiopathology
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Gene Expression / physiology
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Humans
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Mice
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Molecular Biology
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Rats
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Syndrome