FIV induced encephalopathy: early brain lesions in the absence of viral replication in monocyte/macrophages. A pathogenetic model

L Silvotti; A Corradi; G Brandi; A Cabassi; M Bendinelli; M Magnan; G Piedimonte

doi:10.1016/s0165-2427(96)05617-6

FIV induced encephalopathy: early brain lesions in the absence of viral replication in monocyte/macrophages. A pathogenetic model

Vet Immunol Immunopathol. 1997 Mar;55(4):263-71. doi: 10.1016/s0165-2427(96)05617-6.

Authors

L Silvotti¹, A Corradi, G Brandi, A Cabassi, M Bendinelli, M Magnan, G Piedimonte

Affiliation

¹ Istituto di Anatomia Patologica Veterinaria, Università di Parma, Italy.

PMID: 9151398
DOI: 10.1016/s0165-2427(96)05617-6

Abstract

FIV induced encephalopathy represents a model for the study of the neuropathogenesis of AIDS. It has yet to be determined whether massive viral replication is a prerequisite for the development of early brain lesions. Using a drug delivery system developed by us, we have shown that early encephalic lesions appear in FIV infected subjects even when viral transport within the brain has been markedly reduced or blocked.

MeSH terms

Acute Disease
Animals
Brain Diseases / pathology
Brain Diseases / veterinary*
Cat Diseases / pathology*
Cat Diseases / virology
Cats
Cells, Cultured
Disease Models, Animal
Immunodeficiency Virus, Feline / physiology*
Lentivirus Infections / pathology
Lentivirus Infections / veterinary*
Lentivirus Infections / virology
Macrophages / virology*
Macrophages, Peritoneal / virology
Monocytes / virology*
Virus Replication*