Aggressive natural killer (NK) cell lymphoma: report of a pediatric case and review of the literature

Leuk Lymphoma. 1997 Apr;25(3-4):387-92. doi: 10.3109/10428199709114178.

Abstract

We report a rare pediatric case of aggressive natural killer (NK) cell lymphoma, characterized by acute onset hepatosplenomegaly and respiratory distress, and infiltration by large granular lymphocytes with the phenotype of CD3-CD16-CD56+. The patient has remained in complete remission after short-pulse intensive chemotherapy, and myeloablative therapy followed by allogeneic bone marrow transplantation. We compare our case with 7 other children with NK cell leukemia reported from other institutions.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antigens, Surface / metabolism
  • Bone Marrow Transplantation
  • Child
  • Female
  • Fever
  • Graft vs Host Disease / drug therapy
  • Herpesvirus 4, Human
  • Humans
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / pathology*
  • Leukemia / pathology
  • Liver / pathology
  • Lymphoma / immunology
  • Lymphoma / pathology*
  • Lymphoma / therapy*
  • Male
  • Remission Induction
  • Spleen / pathology

Substances

  • Antigens, Surface