Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation

Bone Marrow Transplant. 1997 May;19(10):1041-3. doi: 10.1038/sj.bmt.1700789.

Abstract

We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years. However, he developed hyperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglobulin antibodies before BMT. The donor had no history of thyroid diseases and showed normal thyroid functions but was positive for anti-thyroglobulin antibodies. Thus, even when the donor is in a subclinical state, autoimmune thyroiditis may be transferred from donors to recipients by BMT.

Publication types

  • Case Reports

MeSH terms

  • Adoptive Transfer
  • Adult
  • Bone Marrow Transplantation / adverse effects*
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / therapy
  • Male
  • Psoriasis / complications
  • Psoriasis / therapy*
  • Thyroiditis, Autoimmune / etiology*
  • Tissue Donors
  • Transplantation, Homologous