Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms

T C McKee; H R Bokesch; J L McCormick; M A Rashid; D Spielvogel; K R Gustafson; M M Alavanja; J H Cardelline 2nd; M R Boyd

doi:10.1021/np970031g

Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms

J Nat Prod. 1997 May;60(5):431-8. doi: 10.1021/np970031g.

Authors

T C McKee¹, H R Bokesch, J L McCormick, M A Rashid, D Spielvogel, K R Gustafson, M M Alavanja, J H Cardelline 2nd, M R Boyd

Affiliation

¹ Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.

PMID: 9170286
DOI: 10.1021/np970031g

Abstract

New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp. (1-7); anti-HIV pterocarpans (8 and 9) and isoflavanoids (12-16 and 18) were elucidated from two tropical plants in the genus Erythrina; and anti-HIV enniatins (20 and 22-23) were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fiber assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alternaria / chemistry
Animals
Anti-HIV Agents / isolation & purification*
Anti-HIV Agents / pharmacology
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Fusarium / chemistry
Humans
Magnetic Resonance Spectroscopy
Mice
Plants, Medicinal / chemistry*
Pyrones / isolation & purification
Pyrones / pharmacology
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Anti-HIV Agents
Antineoplastic Agents
Antineoplastic Agents, Phytogenic
Pyrones
Triterpenes