Contribution to the physically anchored linkage map of the pig

Anim Genet. 1997 Apr;28(2):94-102. doi: 10.1111/j.1365-2052.1997.00084.x.

Abstract

Thirty-three microsatellites have been mapped on the PiGMaP porcine genetic map. By comparison with the previously published PiGMaP maps, the maps of chromosome 2 (140 cM/70 cM) and chromosome 3 (180 cM/110 cM) were extended and new markers were mapped on the p-arm extremity of chromosome 7 and on the centromeric extremity of chromosome 15. New orders are proposed for markers on chromosomes 3 and 17. Six microsatellites isolated from cosmids were also localized on the cytogenetic map by fluorescent in situ hybridization. We tested the subcloning ligation mixture-polymerase chain reaction (SLiM-PCR) method for isolating microsatellites from cosmids. Subcloning is more effective when the cosmid harbours several microsatellites whereas SLiM-PCR is more straightforward when the cosmid contains a single microsatellite. Fifteen anonymous microsatellites were regionally assigned by using a hybrid cell panel. For map integration, the determination of a regional assignment of anonymous microsatellites by using a hybrid cell panel offers an alternative to microsatellite isolation from cosmids and their localizations by in situ hybridization.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Cytogenetics
  • DNA Primers / genetics
  • Female
  • Genetic Linkage*
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Male
  • Microsatellite Repeats / genetics
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Swine / genetics*

Substances

  • DNA Primers

Associated data

  • GENBANK/L29002
  • GENBANK/L29049
  • GENBANK/L30151
  • GENBANK/L31354
  • GENBANK/L31356
  • GENBANK/L31359
  • GENBANK/U77989
  • GENBANK/U77990
  • GENBANK/U77991
  • GENBANK/U77992
  • GENBANK/U77993
  • GENBANK/U77994
  • GENBANK/U77995
  • GENBANK/U77996
  • GENBANK/U77997
  • GENBANK/U77998
  • GENBANK/U77999
  • GENBANK/U78000
  • GENBANK/U78001
  • GENBANK/U78002
  • GENBANK/U78003
  • GENBANK/U78004
  • GENBANK/U78005
  • GENBANK/U78006
  • GENBANK/U78009
  • GENBANK/U78010
  • GENBANK/U78013
  • GENBANK/U78016
  • GENBANK/U78019
  • GENBANK/U78022